| Issue |
BIO Web Conf.
Volume 237, 2026
2026 8th International Conference on Biotechnology and Biomedicine (ICBB 2026)
|
|
|---|---|---|
| Article Number | 01002 | |
| Number of page(s) | 5 | |
| Section | Molecular and Cellular Pathophysiology | |
| DOI | https://doi.org/10.1051/bioconf/202623701002 | |
| Published online | 10 June 2026 | |
Expression Difference of SLC6A4 Gene in Tumor and Normal Tissues and Its Influence on Survival
Art Science and Engineering, University of Rochester, Rochester 14627, USA
* Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
We integrated GEPIA multi-omics database to systematically analyze the expression pattern and prognostic value of SLC6A4 gene in 33 cancers. Key findings revealed significant downregulation in 73.0% of cancer types, especially lung cancer, while it was upregulated in READ and showed no significant difference in BRCA and several other cancers, where lung adenocarcinoma was only 22.6% of normal tissue. Survival analysis showed that SLC6A4 expression was not significantly associated with breast cancer prognosis, but its gene mutation increased the risk of death to 4.1 times that of wild type patients and shortened the median survival time to 28.6 months. This study is the first to map the pan-cancer expression-survival profile of SLC6A4, providing molecular epidemiological evidence for the targeting of the PI3K pathway and the development of mutation detection kits.
© The Authors, published by EDP Sciences, 2026
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.