| Issue |
BIO Web Conf.
Volume 240, 2026
The 2026 International Conference on Biomedicine, Neuroscience and Biostatistics (ICBNB 2026)
|
|
|---|---|---|
| Article Number | 01028 | |
| Number of page(s) | 4 | |
| Section | Biomedicine, Neuroscience and Biostatistics | |
| DOI | https://doi.org/10.1051/bioconf/202624001028 | |
| Published online | 24 June 2026 | |
mRNA-Based Anticancer Immunotherapy: Molecular Design and Delivery Strategies with Melanoma as a Model
1 School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, China
2 Faculty of Biology, Medicine and Health, The University of Manchester, M13 9PL Manchester, United Kingdom
* Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
mRNA-based anticancer immunotherapy has become a promising cancer treatment strategy, especially after the success of mRNA vaccine technology. mRNA therapeutics can trigger strong immune responses with the expression of tumor-specific antigens and immunomodulatory proteins. This review outlines the molecular design principles of mRNA constructs, including optimization approaches. In addition, current delivery strategies, particularly lipid nanoparticles, are discussed as well. Focused on the high tumor mutation load and immunogenicity of melanoma, it is an ideal model for mRNA-based immunotherapy. Despite the advances, several challenges remain, especially those related to delivery efficiency and immunosuppressive tumor microenvironment. In the future, the strategies of integrating and optimizing the delivery systems, personalizing neoantigen design and combined therapy are expected to promote the clinical application of mRNA-based cancer therapeutics.
© The Authors, published by EDP Sciences, 2026
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