Precision medicine and traditional chinese medicine of dialogue

The precision medicine is more precise individualized medicine, based on the patient 's genes or physiological to formulate the specific treatment plan, for the realization of individualized treatment of various diseases to provide valuable information.But with the progress of modern science and technology, modern medicine dependence on medical instruments are too serious, traditional ways are gradually forgotten.If the machine depends on the instrument test results too serious which don't combined with the actual diagnosis, the cause of misdiagnosis, so we should pay attention to the overall analysis of diseases and systematic diagnosis and examination, use of the overall treatment concept traced back to find the cause of Traditional Chinese Medicine, finally decide to select a best treatment plan.We should use the dialectical attitude to look at the precise medical.Not blindly requirements according to the road of precision medicine of Traditional Chinese Medicine to go, to shine in himself field, form of self characteristic of Traditional Chinese Medicine.Can learn some of the advantages of accurate concept, the good and rejecting the bad, hope the Traditional Chinese Medicine in the modern environment more walk more far. The concept of precision medical is drugs in the future will be customized fo r each indiv idual or a small group of people, At present using mass production of a class of drugs, and to all the people of the same kind of disease take the same medicine situation will be gradually eliminated.It is more precise individualized medicine, based on a genetic or biological t reatment to customize.As follow is the Specific steps:First, in patients with a large number of indiv iduals and genome sequencing to build a huge medical data information database, and then through the analysis of the genetic information of the comparison of different ind ividuals, to further understand the common cause and individual cause of various diseases, in the last developed for particular patients with specific diseases pathogenic gene targeted drugs and therapies, of course, also for personalized preventive care for healthy people.Each patient has a "card", Doctor "swipe" identification informat ion, symptomatic to people;To see a doctor and treating according to each person's genome, take medication as the main body of the existing med ical reform, thus will influence and change the future of medical care, drug development and use.Will also find more and more treatments for cancer and for the realization of individualized treatment of various diseases to provide valuable informat ion. With the concept of precision medical widely promoted and in clin ical application,the effect of the play is also more and more obvious, especially in the cancer therapy has made big contribution, but has some concrete problems to be solved on the clinical app licat ion, precision medical has some farfetched in the face of the whole concept and theory of Traditional Chinese Medicinal and the theory of property of chinese herbs, medicinal herbs of warm, hot, cold, cool, cannot be exp lained by the a Corresponding author: miaomingsan @163.com. DOI: 10.1051/ , 010 (2017) 708010 BIO Web of Conferences 8 bioconf/201

The concept of precision medical is drugs in the future will be customized fo r each indiv idual or a small group of people, At present using mass production of a class of drugs, and to all the people of the same kind of disease take the same med icine situation will be gradually eliminated.It is more precise individualized medicine, based on a genetic o r biological t reatment to customize.As follow is the Specific steps:First, in patients with a large nu mber of indiv iduals and genome sequencing to build a huge medical data information database, and then through the analysis of the genetic information of the comparison of different ind ividuals, to further understand the common cause and individual cause of various diseases, in the last developed for particular patients with specific diseases pathogenic gene targeted drugs and therapies, of course, also for personalized preventive care for healthy people.Each patient has a "card", Doctor "swipe" identification informat ion, sympto matic to people;To see a doctor and treating according to each person' s genome, take med ication as the main body of the existing med ical reform, thus will influence and change the future of med ical care, drug development and use.Will also find more and mo re treat ments for cancer and for the realization of individualized treatment of various diseases to provide valuable informat ion.With the concept of precision medical widely promoted and in clin ical application,the effect of the play is also more and more obvious, especially in the cancer therapy has made big contribution, but has some concrete problems to be solved on the clinical app licat ion, precision medical has some farfetched in the face of the whole concept and theory of Traditional Chinese Medicinal and the theory of property of chinese herbs, medicinal herbs of warm, hot, cold, cool, cannot be exp lained by the concept of precision medicine, in the face of these problems we need to correct view p recision med icine, reasonable applied to clinical therapy.

The application of precision medical
Precision med ical plays a significant ro le in the treat ment of d iseases , such as heart cerebrovascular disease, cancer, neurodegenerative diseasesand so on.

Precise application in cardiovascular medicine
In recent years, on the basis of the gene sequencing of precision medical get rapid development, heart vascular disease, clinical go up to with hypertrophic cardio myopathy, sudden cardiac death, such as genetic hypertension monogenic disease genetic cardiovascular disease has through genetic testing for early diagnosis, early warn ing and targeted therapy, pathogenic gene mutation carriers and their families for genetic screening, genetic block, predict curat ive effect, individualized treat ment, cardiovascular field will beco me the new direction of precision medical.

Precision medical applications in cancer
Presently, precision medical in the treatment of cancer get good progress and results.For examp le, there are more and more patients with breast cancer, lung cancer, colorectal cancer, and melano ma are applied precise treat ment to cure the disease and tested for genome in treat ment, doctors can according to each person' s genome differences make the best treatment plan.Breast cancer after decades of research, for examp le, has been divided into 10 categories, according to a new system of classification and diagnosis, clinicians can according to different category, take accurate treatment plan to make possible a variety of breast cancer to cure.

Precision medical applications in neurodegenerative diseases
Neurodegenerative disease is a kind of co mp lex diseases, includin g Alzheimer's disease, Parkinson' s disease, Amyotrophic Amyotrophic lateral sclerosis, such as its pathogenesis, early d iagnosis difficult, complex causes the lack of treat ment, the serious influence the patient' s quality of life and work.Currently, neurodegenerative diseases "precision medical" just getting started, there are a lot of work to be carried out.For examp le, the use of genomics, proteomics, metabolo mics technology such as finding more disease related gene, molecular Marker, and by adopting the technology of pharmacogenomics, the development of indiv idualized targeted drugs, "tailored" to use drugs, to achieve the ultimate neurodegenerative diseases, to promote the "precision medical treat ment", better service for patients with med ical treat ment.In early diagnosis, need to be patient of genomics, proteomics, metabolo mics etc informat ion analysis, to fully assess risk of patients;In the treatment of disease, patients with combined drug genome information needed, personalized treat ment options.

Precision medical problems in the treatment of cancer
In tumor treat ment, fo r examp le, has now been confirmed in cancerous cells exist in the process of a large nu mber of genetic mutations, suggesting that most of the mutations, there is no significant effect on tumor occurrence and evolution, but how to determine and accurately interpret these key mutations will not be easy;And the tumor cells in the process of treat ment is not co mpletely passive, tumor cells can evolve through natural selection, or evolution, single drug treatment all cannot kill tu mor cells is also one of the reasons.This is because the tumor is the result of the interaction between genes and environment, environmental factors caused by tumor cell gene structure and function of change, a nd ultimately make tu mor cells to better adapt to the environ ment.Only fro m the tu mor on the one hand, accurate treatment unsolved problem existed, is not to remove a lesion can be cured.Therefore, the precise treatment in clinical med ical treat ment still has a long way to go.

for the treatment of using precise idea of thinking
With the implementation of the concept of "precision medicine", it should be optimistic about the concept, but also should be questioned.Questioning the idea comes fro m the unde rstanding of the disease itself, That is, whether the problem can be accurate diagnosis and treatment.Until today in development of medicine, It can cure d iseases are nu mbered, Most chronic d iseases are usually not just one of the body's problems, but one or mo re of the system's problems,and may be the whole body of one or more of the system is out of the question.What is more important to human health are the result of co mplex mult i-factor co mprehensive effect, at the same time, because each person's physical quality is d ifferent, each kind of disease according to the specific circu mstances of individual patients have different manifestations.So you should see, most of the co mp lexity of the disease is caused by a single factor.Therefore, because the comple xity of the disease itself, which makes the precise concept more stay at the ideal level.

Precision medicine in the application of traditional chinese medicine
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Characteristics of traditional chines e medicine thinking -the whole
The whole concept has a pivotal position in the Trad itional Chinese Medicine, to observe and explore the relationship between the human body and the human body and the external environ men t and the clin ical d iagnosis and treatment of diseases has an important guiding significance, believes that the human body is an organic whole, constitute the various parts of the human body in the physiological, pathological are inseparable, mutual influence; At the same t ime we also recognizes the unity of body and the environment.The unity of internal and external environment, the body's own integrity of the idea, referred to as the overall concept.In some respects, Human beings live in nature, there exist necessary conditions for the survival of hu man beings.At the same t ime, the changes of nature will directly or indirect ly affect the physiological or pathological state of the human body, and the body will react accordingly.Under the influence of the overall concept, Traditional Ch inese Medicine only consider the overall accuracy is the true precision!

Characteristics of traditional chines e medicine treatment-syndrome differentiation
Analysis, identificat ion of disease syndrome is a syndrome d ifferent iation.Identify the cause of the disease, the nature of the site, and then determine where to judge; The disease syndromes performance varied, pathological changes is very co mplex, lesions with different t ime, space and different individuals have different influence on the changes of disease.By syndrome differentiat ion, distinguish between the phenomenon and the essence of the disease, you can seek the treatment.According to the different t ime of onset, different individual characteristics, location and time t o be patient, because the treatment of the person.According to different causes, illness, disease, pathogenesis to determine the specific treat ment methods, and then choose an effective drug, wh ich can also be said to be a precise expression.

Characteristics of Traditional Chinese Medicine -compatibility
Et iology is not unique, the only precise is the narro w sense of precision, For the cause of the compound is accurate.Zhongjing formu la, such as less of its ingredients, but fujin made excellent compatibility, if we change the amount of a medicine in the formu la, it is possible to result in great changes of prescription effect.
In the case of Gu izhi decoction, the party by 90 g cassia twig, peony, licorice, ginger 90 g, 90 g of 12 pieces, 60 g, big ju jube efficacy for muscle functions, to reconcile camp guard, can also be used as a basic prescription for the treat ment of other diseases and other diseases.such as the follo wing: (1) Add Houpu 60g, almond fifty, jieji functions of dispelling wind, gasp for;(2) Increase the amount of the single twig, cassia twig and 150g, namely Gui Gu i Tang, reuse of cassia twig, intended to Wen Tong Xinyang, in order to make kidney water, flush down the inverse;(3)The prescription of cassia twig to peony and Aconite Decoction on the sun card table mistakenly and evil injury Yang invaginations of the pathogenesis and the addition and subtraction, Yang if the injury is not heavy, can be removed if the in jury is heavy Yang peony, resulting in "cold" disease, need to add temperatu re by Fuyang aconite;(4) Based on the reuse of Gu izhi Decoction plus peony Xiaojianzhong decoction is composed of maltose, sweet and sour sweet combination prescription can regulate Yin and Yang.
The application of Gu izh i Decoction to maltose, licorice, ju jube sweet to health priorities, with Gu izhi, Xin Yang Laitong regulating Wei g inger, with peony acidity and camp is pain, replenishing spleen progenitor, provides an important basis for the clin ical med ical treat ment of offspring spleen and stomach diseases.The above party is based on square chmical process, total herbs are not many, but reflects the subtleties of the classic prescription, fully demonstrated the characteristics of a person's diagnosis and treatment of one party.

Traditional Chinese Medicine application features -páo zhì
The drug is according to the condition to use, improve the efficacy, reduce toxicity must be considered is the focus of medication,so drug processing in this action can not be ignored.At the same t ime, taking drug treat ment regimens for efficacy of increase or decrease also have an important influence.
If the drug dosage is two to six times the clothing and a variety of methods.The specific choice of drug med ication, and according to the specific characteristics of pat hogenesis and disease.The meal served drug concentration, rapid effect; to decline Yang, Yin Han Sheng syndrome; for old pain, is a virtual reality of the card to see the three directions; four doses were found only with serious and complicated illness; five times, six times those seen in Angelica four inverse plus Evodia Decoction and ginger pig skin soup; take a small amount of service frequency, mainly to the drug continued constantly.Fro m the above we can see that the application of tradit ional Chines e medicine is also a certain precision at all.

The similarities between Chinese medicine and Precision medicine
Zhang zhongjing of the han dynasty, study of huangdi neijing, the concept of appropriate due to illness better applied to specific diseases,dissolve into the specific prescription.In TCM clin ical syndrome differentiat ion process, also need to grasp the pathogenesis in order to establish the core of treatment.Zhongjingfang spread very long.Secondly, since ancient times are in use, it co mpare d to the updating speed of the western medicine fast, inspire us to think about Traditional Ch inese Medicine formu la "precision medicine".The ancient one, due to illness condition fro m a certain perspective, which belongs to the category of medicine treat ment of indiv idual.
According to the characteristics of TCM syndrome differentiation treat ment, The sick people are different, and the reaction to the disease must be different.Disease have different time, p lace and it will be different; Disease no matter occurrence, develop ment, recovery and so on are not immutable and frozen, such as the SARS virus, its infect ious and biological characteristics will change with the change of the condition such as time, space, thereby increasing the treatment difficult ies, w e according to the characteristics of the disease drug use, so that is the precisely reflected.See the application fro m the overall concept of Western medicine, and can not be completely out of the whole concept to grasp, to comprehensive clinical examination was performed only after an antidote against the disease, at this point, medicine also need to use the whole idea as a foundation, comprehensive inspection of an antidote against the disease in order to better treatment of d iseases.

the difference between TCM and Precise medical
Traditional Ch inese Medicine treatment is mo re dependent on the method of inspection, auscultation and olfaction, inquiry, and pulse-taking and palpation, to an overall understanding of the symptoms of the patients with causes, and symptomatic treat ment.Such as pulse condition, The formation of pulse sequence, and the heart, blood and body flu id are closely related.Its different change reflects the heart strong or weak, relaxat ion, qi-b lood virtual lag changes in the three aspects.Only will be the heart of the fixed, context and the flow of qi-b lood, body fluid together analysis, to reveal the essence of the change of the pulse, What letter what Maicai reasoned, is not like water without source.Just fro m this aspect of pulse, different pulse condition implicating the body all aspects of function, it is only through the overall analysis to suit the remedy to the case to achieve the purpose of treating diseases.In this aspect Traditional Ch inese Medicine treatment notice or as a whole, precise prefer to individualized treat ment.

The problems encountered in the application of Traditional Chinese Medicine
Precise med ical treat ment concept in a person of Tradit ional Chinese Medicine, syndrome differentiation and treat ment aspects are reflected,also play an important role, but in the face of the overall content of property theory in the treat ment of Traditional Chinese Medicine and Traditional Chinese Medicine, you can't explain it, so we should dialectical view of med icine applic at ion in Traditional Chinese Medicine, can not produce a plausible theory of Tradit ional Chinese Tedicine treatment; for example, the Trad itional Chinese Medicine about four, refers to the cold temperature Liangsi different resistance, also known as four.It reflects the vicissitudes of drugs on the body of y in and Yang, co ld and heat changes the tendency.It's not just to show that medicine is to make people feel cold or warm, and modern instru ments can't solve the mystery, it not because of wh ich a specific substance to determine the temperature of drug and cold, so that the precise idea is not all powerful.
Treat ment of d isease of TCM should pay attention to avoid the "no overall plan for a fundamental transformation".Such as the co mmon co ld,co mmon have a bad cold, fever, head and pain and a series of symptoms, Ho wever, due to the different pathogenic factors and physical, it is often characterized by cold, the wind hot cold, heat, and internal heat cold and other different types of evidence, only through the through overall analysis of the patient, to d istinguish clearly what kind the cold, can determine the corresponding treatment methods, to give appropriate treatment, rather than just "hot" fever of local treat ment.So the treat ment should start fro m the overall concept, with the disease treatment, flexib le.

Discussion
Precision t reatment has many advantages in clinical applicat ion, such as accurate positioning of the lesions, reduce the patient's pain and solve some of the co mplicated diseases that are difficu lt to be solved now.at the same time there are a lot of problems need us to solve, to better provide methods for clin ical t reat ment.
With the progress of modern science and technology, precision med icine in the applicat ion process of the instrument is too serious, the traditional diagnosis method was gradually forgotten, although the inspection instrument is accurate and objective, the use of modern science and technology in the diagnosis and treatment has certain advantages, but clinical experien ce is more important, if the The biggest characteristic of Tradit ional Chinese Medicine treat ment is to grasp the patient's overall treat ment, find the source for treat ment.It is the wisdom of the spread of thousands of crystals, but also apply to modern disease treatment.Such as the classic "the headache medicine foot" said,this is fro m the meridian theory.relevant organs lesions occurred.According to the meridian courses route, starting from the overall concept, to find out the source of the disease, which can treat a range of diseases.So we should start from the whole, find the source, combination with the idea of the precise treatment to achieve twice the result with half the effort to disease treatment, better services for patients.But the doctor of Traditional Chinese Medicine treat ment there is a problem, such as the treatment cycle is long, the interaction mechanis m between the drug problems such as unclear, it is also need we dialectical v iew.
Fro m the above discussion we can see that in the concept of treatment of TCM due to illness condition, dialectical treat ment and Ch inese medicine taking method in some degree belongs to the med icine category, we can see that they are common in medical research in the future, the two complementary treatment may beco me a trend, but can not be a requirement for Trat idional Ch inese med icine accord ing toWestern med icine routine to go. each concept all have their own characteristics, and has their own areas of expert ise, in their own field to shine, to form the self characteristic of Chinese medicine,, in order to go out of the country, so that more people recognized, and it is not a simp le precise med ical treat ment concept can be carried forward in traditional Ch inese medicine, advanced the concept of med icine does have merit, you can learn fro m Traditional Chinese Medicine, its essence, to its dregs, not blindly copy,we should use dialectical attitude to treat the precise med icine.Hope that the Trad itional Chinese Medicine in the modern environ ment, the mo re far away fro m the ancients retained the wisdom o f a better use of our lives.

The articles will be quoted as follows:
project team of outstanding scientific and technological innovation in Henan province (TCJ2014 -391), the natural science foundation of Henan province (132300410019), science and technology innovation team of Zhengzhou city (131PCXTD612) mach ine depends on the instrument test results, and can not combine the actual condition, it can lead to misdiagnosis, it is not uncommon in clin ical.This tells us that if we rely solely on the instrument data and the results of the examination, the temporary removal of a lesion site, the temporary relief of the patient suffering, but the follow-up related diseases caused by this can not be without thinking.So in the face of the accurate treat ment of such a deficiency, we should reflect on whether you would have a long and Traditional Chinese Medicine diagnosis and treatment technology without hesitation abandon and into the precise treatment arms.