Botanical coverage of the leading families of medicinal flora of Kazakhstan

The work presents a comprehensive analysis of the phytopharmacological study of 4 fairly large families of the medicinal flora of Kazakhstan, which includes 148 medicinal species: Polygonaceae (42), Caryophyllaceae (41), Poaceae (35), Boraginaceae (30). The analyzed families contain 22 pharmacopoeial species, of which 2 species are included in the Red Book of Kazakhstan. The resource coverage of medicinal species is extremely low; stocks of raw materials were taken into account only for 10 species. The introduction coverage of medicinal plants of these families is higher than the resource one; 56 species have been cultivated, information on the yield of raw materials is available for 7


Introduction
The article is of an overview nature and is based on the materials of screening of the medicinal flora of Kazakhstan according to the annotated listing of species [1]. The analyzed families are presented based on the modern understanding of the status and volume of taxa [2]. The Plantarium and The Plant List Internet resources [3,4] were used for taxonomic adjustment.

Results
Screening of the medicinal flora of Kazakhstan showed presence of 1406 species belonging to 134 families of higher flowering plants in the territory of the Republic. Further analysis revealed 7 families leading by the number of medicinal species: Asteraceae (196 species), Rosaceae (89), Lamiaceae (78), Fabaceae (78), Ranunculaceae (75), Apiaceae (69) and Brassicaceae (63), a detailed analysis of which was given in our previous work [5]. Boraginaceae Juss. family has 30 species, 18 genuses of medicinal plants in the territory of Kazakhstan. In the biomorphological spectrum, all species of the family are herbaceous plants: perennials -13, annuals -9, biennials -8 species. About a third of the species have a wide range, being represented by the Palearctic (Anchusa officinalis L., Echium vulgare L., etc.) and Holarctic (Myosotis scorpioides L.) species. There are 5 species with Central Asian mountain ranges (Onosma dichroantha Boiss., Lappula Moench species, etc.), grow only in Altai -2 (Cerinthe minor L. and Lappula redowskii (Hornem.) Greene), in total for the mountain systems of Altai, Tarbagatai, Tien Shan -10, in plain steppe Kazakhstan -3 species, 3 species -grow everywhere.
In official medicine, only 1 species is known -Symphytum officinale L. and others are used exclusively by traditional medicine. Raw material -grass, contains alkaloids, carbohydrates, triterpenoids, steroids, saponins, cyclitols, nitrogen-containing compounds, organic, phenol carboxylic and higher fatty acids, tannins, fatty oil. It is used as a hemostatic, emollient, wound healing, immunomodulating, antihormonal, antispasmodic, antiviral, antitumor agent. Most members of this family are characterized by the presence of saponins, alkaloids, flavonoids, coumarins, cyclitols, carbohydrates, phenolic and fatty acids and etc. They are used in the same way.
The resources of these species in the territory of Kazakhstan have not been determined. Data on the production cultivation of the species of the family have not been found in the available literature; information on the introduction is available for 7 species of this family.
For Caryophyllaceae Juss. family only 41 medicinal species (20 genera) are identified. The largest genera are Dianthus L. and Stellaria L. (6 each), eleven genera have 1 species each. In biomorphological terms, most species are herbaceous plants: perennials -28 species (69%), annuals -5, semi-shrubs -2, 6 species have a mixed biomorphological type. In phytogeographical respect, most medicinal species of the family have wide ranges, species with Altai, Siberian Mountain, Central Asian Mountain and steppe types of ranges are less common.
They are used almost exclusively by traditional medicine; only 3 species are used in official medicine: Allochrusa gypsophiloides (Regel) Schischk, A. paniculata (Regel & Herder) Ovcz. & Czukav. and Saponaria officinalis. The species of the family are rich in ecdysteroids of various structures which have a tonic, adaptogenic, restorative effect; saponins (tritrepene, steroid), which are used as an expectorant agent; a number of flavonoids are derivatives of quercetin, genin and, in small amounts, alkaloids.
Resources have been identified only for Allochrusa gypsophiloides [6] whose commercial thickets were found on the foothill plain of the Beltau ridge in the South Kazakhstan region.
In terms of introduction medicinal plants of this family have practically not been studied. Cultivation experiments are available for 11 species that were grown in the botanical gardens of Kazakhstan as ornamental crops. Attempts of commercial growing of Allochrusa gypsophiloides showed very low profitability of the plantation, although the average yield of dry Allochrusa root in the 4 th year of cultivation reached 23.1 c/ha.
The Poaceae Barnhart family includes 35 species, 29 genera of medicinal plants in the territory of Kazakhstan (annuals -7, perennials -28 species). The raw material is the whole plant with roots. Species have diverse natural components and some of them may applied as antidiabetic agents (g. Phramites Adans.) [7]. Most often they are used as antiseptic, anti-inflammatory, hemostatic and sedative agents.  In folk medicine, a rare species, Rheum wittrockii C.E. Lundstr. is widely used.
The described families contain diverse biologically active components and most wellknown flavonoids, coumarins, steroids, triterpenes, alkaloids and etc. Polygonaceae and Caryophyllaceae fam. species found as a source of flavonoids and saponins. In recent decades active scientific research has been carried out for studies on chemical constitutes of cereals (Poaceae fam.) as a source of new pharmacological active components and in many plants of these systematic group have been tested and identified a range of activities as antibacterial, growth-inhibiting and antimycotic properties which makes it possible to use them in the treatment of malignant neoplasms.
The resource knowledge of medicinal species of these families is extremely low, stocks of raw materials were taken into account only for 10 species: Allochrusa gypsophiloides, Agropyron cristatum, Phragmites australis and 7 species of the family Polygonaceae, which in general constitutes less than 7% of plant species of the families under consideration.
The introduction coverage of medicinal plants of the aforementioned families is significantly higher than the resource coverage, but it is also very limited in comparison with the general introduction knowledge of medicinal plants in Kazakhstan, which, on average, is about 50%. In the botanical gardens of Kazakhstan, 56 species were grown (38% of the total number of species of the analyzed families), 1 species was tested in