Gut Microbiota Dysbiosis and Diabetes: Causal Relationship, Pathogenic Mechanisms, and Clinical Applications

Open Access

Issue		BIO Web Conf. Volume 240, 2026 The 2026 International Conference on Biomedicine, Neuroscience and Biostatistics (ICBNB 2026)


Article Number		01027
Number of page(s)		10
Section		Biomedicine, Neuroscience and Biostatistics
DOI		https://doi.org/10.1051/bioconf/202624001027
Published online		24 June 2026

P. Saeedi, I. Petersohn, P. Salpea, B. Malanda, S. Karuranga, N. Unwin, R. Williams, Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice, 157, 107843 (2019) https://doi.org/10.1016/j.diabres.2019.107843 [Google Scholar]
O. Bajinka, Y. Tan, A. Darboe, I. G. Ighaede-Edwards, K. A. Abdelhalim, The gut microbiota pathway mechanisms of diabetes. AMB Express, 13, 16 (2023) https://doi.org/10.1186/s13568-023-01520-3 [Google Scholar]
R. A. DeFronzo, E. Ferrannini, L. Groop, R. R. Henry, W. H. Herman, J. J. Holst, F. B. Hu, C. R. Kahn, I. Raz, G. I. Shulman, D. C. Simonson, M. A. Testa, R. Weiss, T2D mellitus. Nature Reviews Disease Primers, 1, 15019 (2015) https://doi.org/10.1038/nrdp.2015.19 [CrossRef] [PubMed] [Google Scholar]
M. Gurung, Z. Li, H. You, R. Rodrigues, D. B. Jump, A. Morgun, N. Shulzhenko, Role of gut microbiota in T2D pathophysiology. EBioMedicine, 51, 102590 (2020) https://doi.org/10.1016/j.ebiom.2019.11.051 [Google Scholar]
S. Razavi, N. Amirmozafari, A. Z. Bialvaei, F. Navab-Moghadam, M. E. Khamseh, F. Alaei-Shahmiri, M. Sedighi, Gut microbiota composition and type 2 diabetes: Are these subjects linked together? Heliyon, 10, e39464 (2024) https://doi.org/10.1016/j.heliyon.2024.e39464 [Google Scholar]
R. Mashal, A. Al-Muhanna, S. Khader, A. Khudair, A. Khudair, A. E. Butler, The role of the gut microbiome in type 2 diabetes mellitus. International Journal of Molecular Sciences, 26, 11412 (2025) https://doi.org/10.3390/ijms262311412 [Google Scholar]
E. E. Canfora, J. W. Jocken, E. E. Blaak, Short-chain fatty acids in control of body weight and insulin sensitivity. Nature Reviews Endocrinology, 11, 577–591 (2015) https://doi.org/10.1038/nrendo.2015.128 [Google Scholar]
Z. Mei, F. Wang, A. Bhosle, D. Dong, R. Mehta, A. Ghazi, Y. Zhang, Y. Liu, E. Rinott, S. Ma, E. B. Rimm, M. Daviglus, W. C. Willett, R. Knight, F. B. Hu, Q. Qi, A. T. Chan, R. D. Burk, M. J. Stampfer, I. Shai, R. C. Kaplan, C. Huttenhower, D. D. Wang, Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes. Nature Medicine, 30, 2265–2276 (2024) https://doi.org/10.1038/s41591-024-03067-7 [Google Scholar]
K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I. I. Ivanov, Y. Umesaki, K. Itoh, K. Honda, Induction of colonic regulatory T cells by indigenous clostridium species. Science, 331, 337–341 (2010) https://doi.org/10.1126/science.1198469 [Google Scholar]
V. K. Ridaura, J. J. Faith, F. E. Rey, J. Cheng, A. E. Duncan, A. L. Kau, N. W. Griffin, V. Lombard, B. Henrissat, J. R. Bain, M. J. Muehlbauer, O. Ilkayeva, C. F. Semenkovich, K. Funai, D. K. Hayashi, B. J. Lyle, M. C. Martini, L. K. Ursell, J. C. Clemente, J. I. Gordon, Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice. Science, 341, 1241214 (2013) https://doi.org/10.1126/science.1241214 [Google Scholar]
N. Kassaian, A. Aminorroaya, A. Feizi, P. Jafari, M. Amini, The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trials, 18, 148 (2017) https://doi.org/10.1186/s13063-017-1885-8 [Google Scholar]
D. Zeevi, T. Korem, N. Zmora, D. Israeli, D. Rothschild, A. Weinberger, O. Ben-Yacov, D. Lador, T. Avnit-Sagi, M. Lotan-Pompan, J. Suez, J. A. Mahdi, E. Matot, G. Malka, N. Kosower, M. Rein, G. Zilberman-Schapira, L. Dohnalová, M. Pevsner-Fischer, E. Segal, Personalized nutrition by prediction of glycemic responses. Cell, 163, 1079–1094 (2015) https://doi.org/10.1016/j.cell.2015.11.001 [Google Scholar]
D. P. Baars, M. F. Fondevila, A. S. Meijnikman, M. Nieuwdorp, The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes. Cell Host & Microbe, 32, 1280–1300 (2024) https://doi.org/10.1016/j.chom.2024.07.017 [Google Scholar]
X. Niu, Y. Wang, L. Huang, P. Guo, S. Zhang, Y. Sun, M. Jin, Effect of oral metformin on gut microbiota characteristics and metabolite fractions in normal-weight type 2 diabetic mellitus patients. Frontiers in Endocrinology, 15, 1397034 (2024) https://doi.org/10.3389/fendo.2024.1397034 [Google Scholar]
D. Song, G. Feng, Y. Ma, Y. Shi, C. Qian, C. Wang, J. Xu, Y. Li, X. Wang, N. Fan, W. Dong, X. Li, J. Fan, L. Chu, F. Gao, S. He, J. Wang, S. Wang, H. Zhou, Q. Gu, H. Wang, B. Feng, H. Zhang, X. Zhang, L. Li, E. Fan, Y. Wang, M. Wu, Y. Zhang, A. Huang, J. Teng, Y. Zhu, R. Zhai, X. Ding, C. Zhang, Y. Peng, Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial. Nature Communications, 16, 11506 (2025) https://doi.org/10.1038/s41467-025-66498-x. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.