The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes

Federal State Budgetary Educational Institution of Higher Education “Saint Petersburg State University of Veterinary Medicine”, 5, st. Chernigovskaya, Saint Petersburg, 196084, Russia

^* Corresponding author: nir@spbguvm.ru

Abstract

The aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals. The relevance is due to the active development of agriculture and increased interest in a detailed study of the cytochrome P450 system for obtaining high-quality livestock products. This work highlights the functional significance of the enzyme Nicotinamide-β- adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the processes of activation of cytochromes P450. An analysis of existing data on the interaction of Nicotinamide-β-adenine dinucleotide phosphate-H- cytochrome P450 oxidoreductase with other activating enzymes is carried out. The work is based on the analytical processing of scientific publications, as well as the results of experiments and current statistical reports on the development of animal husbandry. It was established that the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450-oxidoreductase ensures the course of a number of vital reactions. Analysis of data on the interaction of Nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450-oxidoreductase with other enzymes showed the complexity of the mechanisms of metabolism regulation in highly productive animals.