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A control population of human ventricular electro-mechanical models. A Traces of action potential (AP), Ca2+ transient (CT) and force twitch (FT) in the 240 models in the calibrated population. B Ionic parameter profile of the calibrated population, shown as scaling factors with respect to the baseline model. Central mark at box-plots corresponds to the median, box limits are the 25th and 75th percentiles, and whiskers extend to the most extreme data points. C Distributions of AP, CT and FT biomarkers in the calibrated population (blue histograms) and experimental ranges (black lines): TTF, time to peak force; FTD, force twitch duration; other abbreviations as defined in Table 1.
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