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Fig. 2.


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A Classification of models adverse events during aging. Colour maps indicate “Norm” (green), “Risky” (blue tones), “RA” (orange), and “ImP” (rose) classes in the ageing populations. “Risky” class contains models showing ΔAPD90>6% events. Top frequency diagrams show results of age-related deviation of individual parameters, bottom diagram shows classification for 60 ageing populations with 4 parameter varied. Dashed line shows smoothed borderline between classes. B Fraction of ImP models and arrhythmogenic score dependencies on the age-related parameter deviation. Orange, green, red and purple lines show dependencies at GCaL, KNaCa, Gto and Vmax_up individual modulation, respectively. Black dots show scatter plots for 60 ageing models with blue linear regression lines (p < 0.01).

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