Table 1.
Experimental action potential (AP), Ca2+ transient (CT) and force twitch (FT) biomarker ranges used to calibrate the control population of human ventricular electro-mechanical in silico models and extended ranges for biomarkers used to classify non-ImP models in ageing populations.
| Control | |||||
|---|---|---|---|---|---|
| Biomarker | Min Value | Max Value | Biomarker | Min Value | Max Value |
| Vrest | -95mV | -80mV | CTpeak | 0.5 11M | 2.5 11M |
| Vpeak | 10mV | 55mV | CTDpeak | 50 ms | |
| dV/dtmax | 100V/s | 1000V/s | CTD50 | 65 ms | 420 ms |
| APD40 | 85ms | 320ms | CTD90 | 220 ms | 785 ms |
| APD50 | 110ms | 350ms | FTd | 10 | |
| APD90 | 180ms | 440ms | FTpeak | 150 | |
| Tri90-40 | 50ms | 150ms | FTpeak/FTd Ageing | 4 | 50 |
| Biomarker | Min Value | Max Value | Biomarker | Min Value | Max Value |
| CTpeak | 3.0 iiM | FTd | 10 | ||
| CTD90 | 900ms | APD90 | 900ms | ||
Abbreviations: Vrest, resting membrane potential; dV/dtmax, maximum upstroke velocity; Vpeak, peak voltage; CTd, CTpeak, Ca2+ transient diastolic and peak values; FTpeak, FTd, systolic and diastolic force during the twitch. APDxx, AP duration at XX% of repolarization; Tri90-40, AP triangulation, defined as the difference between APD90 and APD40; CTDXX, Ca2+ transient duration at XX% of decay. Both AP and Ca2+ duration’s were computed starting from the instant of maximum dV/dtmax.
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