The role of thrombophilia genes in the clinical implementation of arterial and venous thrombosis in newborns

Open Access

Table 2.

Comparative study of frequencies of enzymes genes polymorphisms of plasma, platelet, fibrinolytic links of hemostasis system in observation groups

Polymorphism	Main group, n=463		Control group, n=57		p (χ²)≤
Polymorphism	n	%	n	%
F1: FGB -455 G/G	27	58.7	48	84.8	0.004
F1: FGB -455 G/A	15	32.6	8	13.4	0.025
F1: FGB -455 A/A	4	8.7	1	1.75	0.104
F1:G/A+ A/A	19	41.3	9	15.7	0.004
F2: 20210 G/G	42	91.3	56	98.25	0.104
F2: 20210 G/A	4	8.7	1	1.75	0.104
F2: 20210 A/A	-	-	-	-	-
F2: 20210 G/A+ A/A	4	8.7	1	1.75	0.104
F5: Leiden 1691 G/G	46	100	57	100	_-
F5: Leiden 1691 G/A	-	-	-	-	-
F5: Leiden 1691 A/A	-	-	-	-	-
F5: Leiden 1691 G/A+ A/A	^-	^-	^-	^-	^-
PAI-1-675 5G/5G	9	19.5	33	57.1	0.001
PAI-1-675 5G/4G	18	39.2	20	35.7	0.673
PAI-1 -675 4G/4G	19	41.3	4	7.2	0.001
PAI-1 -675 5G/4G+4G/4G	37	80.4	24	42.1	0.001
FactorVII G10976A G/G	40	87	53	92.8	0.305
FactorVII G10976A G/A	6	13	4	7.2	0.305
FactorVII G10976A A/A	-	-	-	-
FactorVII G10976A G/A+ A/A	6	13	4	7.2	0.305
Factor XIII Val34Leu	30	65.2	41	71.4	0.465
G/G	16	34.8	16	28.6	0.465
Factor XIII Val34Leu	-	-	-	-	-
G/T Factor XIII Val34Leu T/T Factor XIII Val34Leu G/T+ T/T	16	34.8	16	28.6	0.465
ITGA2 807 C/C	21	45.6	32	56.1	0.290
ITGA2 807 C/T	15	32.6	24	42.2	0.324
ITGA2 807 T/T	10	21.8	1	1.75	0.002
ITGA2 807 C/T+ T/T	25	54.3	25	43.8	0.290
ITGB3 1565 T/T	30	65.2	41	72	0.465
ITGB3 1565 T/C	14	30.4	16	28	0.056
ITGB3 1565 C/C	2	4.4	0	0	0.112
ITGB3 1565 T/C+ C/C	16	34.8	16	28	0.465

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