| Issue |
BIO Web Conf.
Volume 182, 2025
The 3rd International Conference on Food Science and Bio-medicine (ICFSB 2025)
|
|
|---|---|---|
| Article Number | 02001 | |
| Number of page(s) | 6 | |
| Section | Biomedical Research and Applications | |
| DOI | https://doi.org/10.1051/bioconf/202518202001 | |
| Published online | 02 July 2025 | |
Current status and challenges of CAR-T cell therapy in the treatment of haematological cancer
Second Clinical Medica lCollege, NanchangUniversity, Nanchang, 330031, China
* Corresponding author: Yu15170027183@163.com
Chimeric Antigen Receptor T (CAR-T) cell therapy is a promising cellular immunotherapy that involves the use of genetically modified T cells to target and combat hematological malignancies. This approach has shown significant effectiveness and has emerged as a key area of interest in oncological treatment. Despite its potential, the path to broader application is fraught with challenges including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), drug-resistant relapses, side effects, and the high costs associated with manufacturing. These issues have constrained the wider adoption of CAR-T cell therapy. This paper outlines key advancements in the clinical trials of CAR-T cell therapy within the scope of hematological oncology and identifies the primary challenges encountered. The objective of this study is to provide insights that may inform the development of future CAR-T therapies for hematological tumors.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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