BIO Web of Conferences
Volume 6, 2016Electro-Activity of Biological Systems
|Number of page(s)||1|
|Published online||22 March 2016|
Voltage-gated calcium channels: Structure, permeability and inactivation properties
IBMM UMR 5247, 1919 Route de Mende, Montpellier, France
a Corresponding author: firstname.lastname@example.org
Our group has been interested in the structure and function of voltage-gated Ca2+ channels since many years. We have tried to combine molecular cloning, site-directed mutagenesis, heterologous expression, electrophysiological recordings and fluorescence imaging to identify the structures and molecular motions and understand the molecular mechanisms that are responsible for several biophysical properties of these channels. In this talk I will present you a brief overview of this work with a special emphasis on the voltage-dependent inactivation and channel selectivity toward divalent cations. Several references taken from studies on voltage-gated K+ channels will introduce several parts of this presentation.
© Owned by the authors, published by EDP Sciences, 2016
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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