Down-regulation of cystathionine-γ-lyase/H2S system inhibits cell growth in human breast cancer MDA-MB-231 cells

Jing You; Mingming Ma; Juan Ye; Xiaoyan Shi; Tianxiao Wang

doi:10.1051/bioconf/20170801034

All issues

Volume 8 (2017)

BIO Web Conf., 8 (2017) 01034

Abstract

Open Access

Issue		BIO Web Conf. Volume 8, 2017 2016 International Conference on Medicine Sciences and Bioengineering (ICMSB2016)


Article Number		01034
Number of page(s)		7
Section		Session I: Medicine
DOI		https://doi.org/10.1051/bioconf/20170801034
Published online		11 January 2017

BIO Web of Conferences 8, 01034 (2017)

Down-regulation of cystathionine-γ-lyase/H₂S system inhibits cell growth in human breast cancer MDA-MB-231 cells

Jing You, Mingming Ma, Juan Ye, Xiaoyan Shi and Tianxiao Wang^a

College of Pharmacy, Henan University, Kaifeng 475004, Henan Province, China

^a Corresponding author: wtx1975@126.com

Abstract

Hydrogen sulfide (H₂S), as the third gasotransmitter, plays important roles in cancer biological processes. Endogenous H2S can possess pro-cancer functions. Cystathionine-γ-lyase (CSE), one of main metabolic enzymes synthesizing H₂S, possesses important roles in the development and progression of cancer. In the present study, the roles of CSE/H2S system in human breast cancer cells were investigated. It was observed that CSE was expressed in human breast cancer MDA-MB-231 cells and inhibition of endogenous CSE/H₂S significantly reduced the cell viability and inhibited cell growth and proliferation in MDA-MB-231 cells. Meanwhile, CSE knockdown induced apoptosis of MDA-MB-231 cells and inhibited migration of MDA-MB-231. In conclusion, CSE/H₂S system possesses important roles in human breast cancer cells.

The authors would like to acknowledge the financial assistance provided by a grant from the Key Science and Technology Fund of Henan Province (No. 142300410128) in China.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.