BIO Web Conf.
Volume 8, 20172016 International Conference on Medicine Sciences and Bioengineering (ICMSB2016)
|Number of page(s)||5|
|Section||Session I: Medicine|
|Published online||11 January 2017|
Preparation of 5-fluorouracil loaded chitosan microparticle and its drug release properties
Department of Environment and Chemical Engineering, Dalian University, Dalian, China
Chitosan is one kind of good biocompatible polymer and is suitble for drug carriers. Preparation of 5-fluorouracil (5-Fu) loaded chitosan (CS) particles and in vitro release experiment were performed using ionic crosslinking method with sodium tripolyphosphate (TPP) as crosslinker. The optimal preparing parameters were verified by 5-Fu release experiments. The drug loading, and release behavior of drug loaded microparticles in vitro were investigated. The optimal preparation conditions were: the temperature 25°C, the ratio of CS to TPP 5:1, the CS concentration 1.5g/L, stirring speed 650rpm. Under these conditions, the drug loading of particles was up to 45%.
© The Authors, published by EDP Sciences, 2017
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