| Issue |
BIO Web Conf.
Volume 8, 2017
2016 International Conference on Medicine Sciences and Bioengineering (ICMSB2016)
|
|
|---|---|---|
| Article Number | 01058 | |
| Number of page(s) | 5 | |
| Section | Session I: Medicine | |
| DOI | https://doi.org/10.1051/bioconf/20170801058 | |
| Published online | 11 January 2017 | |
Preparation of 5-fluorouracil loaded chitosan microparticle and its drug release properties
Department of Environment and Chemical Engineering, Dalian University, Dalian, China
a Corresponding author: limingming@dlu.edu.cn
b Corresponding author: zhanshiping@dlu.edu.cn
Chitosan is one kind of good biocompatible polymer and is suitble for drug carriers. Preparation of 5-fluorouracil (5-Fu) loaded chitosan (CS) particles and in vitro release experiment were performed using ionic crosslinking method with sodium tripolyphosphate (TPP) as crosslinker. The optimal preparing parameters were verified by 5-Fu release experiments. The drug loading, and release behavior of drug loaded microparticles in vitro were investigated. The optimal preparation conditions were: the temperature 25°C, the ratio of CS to TPP 5:1, the CS concentration 1.5g/L, stirring speed 650rpm. Under these conditions, the drug loading of particles was up to 45%.
© The Authors, published by EDP Sciences, 2017
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