The marker level of endogenous intoxication in the midst of bronchopneumonia and during the convalescence of calves

¹ All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy, 394087 Voronezh, Russia
² All-Russian Research and Technology Institute of Biological Industry, 107140 Moscow, Russia
³ Kuban State Agrarian University named after I. T. Trubilin, 350044 Krasnodar, Russia

^* Corresponding author: exterapi@yandex.ru

Abstract

The research on the level of markers of endogenous intoxication in the midst of bronchopneumonia and during convalescence in calves was conducted in conditions of a complex for feeding young cattle. The experiment involved calves aged 4–5 months, group 1 – clinically healthy (n = 30), group 2 – animals with bronchopneumonia with moderate severity of the disease (n = 72) subjected to full treatment. Blood sampling was carried out the day the groups were formed (in calves from group 2, this is the period of “high disease”), as well as on days corresponding to days 1, 3, 6, 10, 13, 18, and 25 after the disappearance of specific symptoms of bronchopneumonia. From the markers of endogenous intoxication syndrome in the blood, the content of medium-weight molecules (AWM), the sorption capacity of erythrocytes, non-erythrocyte hemoglobin by the hemoglobin cyanide method, and malondialdehyde were determined. Studies have shown that in 37.5 % of those who have suffered, intoxication markers disappear within 10–13 days after completing the course of treatment, and in 41.7 % of calves after positive dynamics, the AWM level increases at 10–13 days at a wavelength of 237 nm, which indicates activation of the resorptive mechanism of autointoxication and the risk of relapse. At the same time, the dynamics of recovery processes in 20.8 % of patients who were ill was characterized by normalization of most of the studied parameters, but by maintaining an increased level of lipid peroxidation products and transmembrane hemoglobin loss, which can cause secondary anemia and re-illness.