Problem of chronic endometritis in cows and ways to solve it

¹ All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy, 394087 Voronezh, Russia
² Saint-Petersburg State Academy of Veterinary Medicine, 196084 St. Peterburg, Russia

^* Corresponding author: mikhalevvit@yandex.ru

Abstract

Chronic endometritis is diagnosed on average in 18.1 % of infertile cows. With chronic endometritis, the uterus has a pronounced cavity of 18.4±0.9 mm (11–35 mm), while the wall thickness of the uterus is on average 8.7±0.37 mm. Morphometrically chronic endometritis is characterized by a decrease in the fraction of functionally active elements of the endometrium (integument epithelium, uterine glands, blood vessels) to 12.17 %. In the development of chronic endometritis, cows compared with clinically healthy animals showed an increase in leukocyte content by 12.2 %, monocytes by 2.5 times, creatinine by 29.7 %, average molecular peptides by 25.0 %, and endogenous intoxication index by 25.4 %, circulating immune complexes by 38.5 %, with a decrease in the bactericidal and lysozyme activity of blood serum, respectively by 10.7 and 12.9 % and phagocytic activity of leukocytes by 12.4 %. The effectiveness of the application of the developed method for the treatment of chronic endometritis, involving the use of aminoseleton five times with a 72-hour interval at a dose of 30, 35, 40, 45 and 50 ml, magestrofan on the 1st and 13th days at a dose of 2 ml, uterotone on 3rd, 4th and 5th days at a dose of 10 ml and intrauterine administration of primalact on 1st-3rd days at a dose of 20 ml, is 88.0 %. Recovery of animals after the treatment is accompanied by a decrease in the inflammatory response, endogenous intoxication, normalization of liver and kidneys, an increase in overall non-specific resistance and a decrease in uterine microbial contamination.