Multicenter Epidemiological Study of Osteoporotic Fractures in Eurasia (EVA Study). A step towards reducing the burden of age-related diseases

¹ Ural State Medical University, 620028, Repina Str., 3, Ekaterinburg, Russia
² Mechnikov North West State Medical University, 191015, Kirochnaya Str., 41, St.Petersburg, Russia
³ Artashat Medical Center, 0701, Aram Khachaturyan Str., 7, Artashat, Armenia
⁴ Gomel State Medical University, 246050, Lange Str., 5, Gomel, Belarus
⁵ State University of Medicine and Pharmacy, 2004, Stefan cel Mare si Sfant blvd., 165, Chisinau, Republic of Moldova
⁶ Asfendiyarov National Medical University, 050000, Tole bi Str., 94, Almaty, Kazakhstan
⁷ Republican Medical Center for Endocrinology, Tashkent, Uzbekistan

^* Corresponding author: zakroeva.alla@mail.ru

Abstract

To extend elderly patients’ active longevity, practitioners all over the world need a precise clinical instrument to assess the 10-year osteoporotic fractures probability and choose the optimal preventive intervention. The purpose of this research is to assess major osteoporotic (OP) fractures incidence in CIS countries and to create country-specific computing FRAX clinical prediction tools. Method. We carried out a cohort population-based study (EVA) in Russia, Belarus, Armenia, Moldova, Kazakhstan, and Uzbekistan in 2011-2018. The age- and sexspecific OP fracture incidence values were incorporated into the computing FRAX models. Results. We revealed that the highest standardized HP incidence was obtained in Kazakhstan (338 and 255 per 100 000 per year for women and men older than 50 years resp.) and Moldova (331, 0 and 155, 0 per year for women and men resp.), the lowest in Armenia (201 and 136 per 100 000 per year for women and men resp.). The FRAX models showed that in Kazakhstan, Uzbekistan, and Moldova, elderly people had the highest hip fracture probabilities. Estimates reveal that the OP fractures numbers in the EVA-project countries will grow by 1.5-3 times by 2050. Conclusion. The created national FRAX instruments should enhance the accuracy of determining fracture probability among older people, help clinicians to make decisions concerning OP prophylactic, and to step forward to reducing the burden of age-related diseases.