| Issue |
BIO Web Conf.
Volume 22, 2020
International Conference “Longevity Interventions 2020” (ICLI 2020)
|
|
|---|---|---|
| Article Number | 02012 | |
| Number of page(s) | 6 | |
| Section | Actual Problems of Medicine | |
| DOI | https://doi.org/10.1051/bioconf/20202202012 | |
| Published online | 06 July 2020 | |
Features of regenerative processes in case of extreme factors influencing the body
Ural State Medical University, 620028, Repina st., bld.3, Yekaterinburg, Russia
* Corresponding author: sv9126000900@yandex.ru
Changes in the specific liver mass, number of single and binucleate cells of different ploidy, mitotic index and alteration index, DNA content and inclusion of 3H-thymidine in DNA of Wistar rats and CBA mice in the following conditions: at 0°C for 3, 7, 14 days for 23 hours per day, and in the highlands conditions (3, 200 m above sea level) for 3 and 30 days. Activation of regenerative processes has been established — proliferation of hepatocytes (mainly diploid) in combination with polyploid cell share reduction, as well as cellular hypertrophy development. Cell dynamics shifts persisted throughout the observation duration and were opposite in direction when growing up and aging.
© The Authors, published by EDP Sciences, 2020
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