| Issue |
BIO Web Conf.
Volume 22, 2020
International Conference “Longevity Interventions 2020” (ICLI 2020)
|
|
|---|---|---|
| Article Number | 02020 | |
| Number of page(s) | 8 | |
| Section | Actual Problems of Medicine | |
| DOI | https://doi.org/10.1051/bioconf/20202202020 | |
| Published online | 06 July 2020 | |
Morphofunctional condition of the pancreatic insular apparatus in old rats with alloxan-induced diabetes and its correction with lipoic acid
1
Ural Federal University named after the first President of Russia B. N. Yeltsin, 620002, Mira st. 19, Yekaterinburg, Russia
2
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049, Pervomayskaya st., 106, Yekaterinburg, Russia
* Corresponding author: klueva.iulia@urfu
The concentration of glucose and glycosylated hemoglobin in the blood of animals increases as a result of physiological aging. This is due to damage to the pancreatic insular apparatus and a decrease in the number and functioning of active β-cells. The development of alloxan-induced diabetes in old rats is characterized by a decrease in the number of islets of Langerhans, an enlargement of the preserved islets, and a sharp decrease in the number of active endocrine cells. The injection of lipoic acid partially corrected the morphofunctional condition of the islets of Langerhans and the biochemical values of the animals’ peripheral blood.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.