| Issue |
BIO Web Conf.
Volume 27, 2020
International Scientific-Practical Conference “Agriculture and Food Security: Technology, Innovation, Markets, Human Resources” (FIES 2020)
|
|
|---|---|---|
| Article Number | 00063 | |
| Number of page(s) | 6 | |
| DOI | https://doi.org/10.1051/bioconf/20202700063 | |
| Published online | 25 November 2020 | |
Experimental evaluation of allergenic properties of Bisphenol-5
1
AhmadullinS Science and Technologies, Research and Development Center, 420139 Kazan, Russia
2
Federal Center of Toxicological, Radiation and Biological Safety – Russian Scientific Research Veterinary Institute, 420075 Kazan, Russia
* Corresponding author: valiullin27@mail.ru
The paper presents the results of preclinical studies of the allergenic properties of a new drug bisphenol-5, which has pronounced anti-radical activity. An experimental study of the antioxidant was carried out in doses of 2, 5, 20 mg/kg in guinea pigs and rabbits. It was shown that bisphenol-5 is not able to cause a general anaphylaxis reaction (anaphylactic shock). By the method of skin applications, the absence of allergenic effects of the drug in animals was found. During the formulation of conjunctival tests in experimental and control animals, signs of hypersensitivity, both immediate and delayed, were not observed with respect to the test drug. Changes in body temperature, pulse rate, and the number of respiratory movements as a result of clinical studies of the state of the animal organism after applying bisphenol-5 were also not recorded. Thus, the drug Besphenol-5 in the studied doses and under the selected experimental conditions does not have a negative effect on the body of laboratory animals and does not have allergenic properties.
© The Authors, published by EDP Sciences, 2020
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