Hepatoprotective effect of hypoxenum against exogenous toxicosis of white rats

Belgorod State Agricultural University named after V.Y. Gorin, Belgorod, 308503, Russia

^* Corresponding author: reznichenko6531@gmail.com

Abstract

Any disturbances in the organism caused by infection, drug administration, vaccination, etc., are accompanied with disturbance of liver functions. Various xenobiotics entering animal organisms with food or water have the highest hepatotoxicity. Thus, an important trend in modern research is a search for substances increasing liver capacity against pathological activities, strengthening its detergent actions. The goal of this research was to study hepatoprotector properties of hypoxenum using the experimental acute toxic hepatitis model in white rats. The acute toxic hepatitis was caused by injecting the rats abdominally with tetrachloromethane in medical paraffin at a dose of 0.4 ml per 100 g of live weight once a day for 3 days. This resulted in disturbance of hepatocytes’ cytoplasmic membranes, accompanied with an increased rate of transamination enzymes and alkaline phosphotase, as well as an acute drop in glucose and total protein. Administration of hypoxenum stopped this pathological process. After the administration of the preparation, the animal’s body weight increased, activity of transamination enzymes and alkaline phosphotase returned to physiological norm, protein and glucose content increased, general physiological condition of the white rats improved. Thus, hypoxenum may be administered to animals as a hepatoprotector at a dose of 50.0 mg/kg of live weight.