The effects of zinc and magnesium ingestion on essential trace-element accumulation in the organs of white rats upon cadmium exposure

Federal Сenter for Toxicological, Radiation and Biological Safety, 420075 Kazan, Republic of Tatarstan, Russia

^* Corresponding author: svetlana150895@yandex.ru

Abstract

Due to high athropogenic loads on the environment, issues surrounding public health and safety in consumable products are being raised with ever-increasing frequency. One toxic metal, whose consumption results in irreparable harm to the health of animals and human is cadmium. To antagonize such toxic effects to human health, magnesium and zinc are considered being essential elements and their combination effects warrant further studies. To this end, we developed a Wistar rat model to look at the combinatorial effects of cadmium with magnesium and zinc consumption on the accumulation of iron and zinc ions in kidney and liver tissues. Our findings suggested that exposure to cadmium ions reduced zinc ion levels in the liver and kidneys, reduced iron ions in the liver (but were increased in the kidneys), decreased magnesium ions in the kidneys but increased their levels within the liver. Moreover, while the consumption of magnesium and zinc ions individually, partially reduced the effects caused by cadmium consumption alone, the simultaneous consumption of zinc and magnesium ions proved to be significantly more effective.