| Issue |
BIO Web Conf.
Volume 28, 2020
The 3rd International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BioMIC 2020)
|
|
|---|---|---|
| Article Number | 02006 | |
| Number of page(s) | 7 | |
| Section | Biomedical Sciences and Engineering | |
| DOI | https://doi.org/10.1051/bioconf/20202802006 | |
| Published online | 17 December 2020 | |
Prospects of fibrinolytic proteases of bacteria from sea cucumber fermentation products as antithrombotic agent
1 Medical laboratory Science Study Program, Universitas Muhammadiyah Semarang, Jl. Kedungmundu No.18, Semarang, Jawa Tengah, 50273 Indonesia
2 Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Jl. Kedungmundu No.18, Semarang, Jawa Tengah, 50273 Indonesia
3 Balai Bio Industri Laut-LIPI (Laboratorium Ilmu Pengetahuan Indonesia), Lombok, Nusa Tenggara Barat, Indonesia
4 Research and Development Center for Marine and Fishery Product Processing and Biotechnology, Ministry of Maritime Affairs and Fisheries of Indonesia, Indonesia
5 Biology Laboratory, Faculty of Mathematics and Natural Sciences, Universitas Diponegoro, Jl. Prof. Sudarto No.13, Tembalang, Semarang, Jawa Tengah 50275, Indonesia
* Corresponding author: snorma@unimus.ac.id
Cardiovascular disease is among the largest contributors of premature mortality in the world caused by inflammation of blood vessels. The abnormalities provoke thrombus formation or thrombosis blocking blood vessels leading to strokes, heart attacks and coronary artery diseases. Increasing percentage of cardiovascular cases and deaths due to thrombosis has attracted researchers to look for newer thrombolysis agents. Commonly used drugs to treat thrombosis has been limited due to various side effects. Therefore, the search for sources of safer and cheaper fibrinolytic enzymes for handling thrombolysis continues. This study aimed to evaluate potentials of fibrinolytic protease of bacteria isolated from fermented seafood (sea cucumber) products as antithrombotic agents. Information was initially gathered from scientific publications identified using web-based tools including PubMed (National Center for Biotechnology Information), Science Direct (Scopus) and Web of Science (Thomson Reuters) using combinations of search terms including “fibrinolytic enzyme protease”, “endopeptidase”, “fermented food”, “sea cucumber”, “thrombolysis therapy,” “thrombolytic agent,” “fibrinolytic bacteria,” “fibrinolysis,” “protease producing bacteria,” “fibrin degradation,” “holothurians,” etc. We also searched for these terms in national and international organization technical reports and databases. This literature review reveals the prospects of fibrinolytic protease enzymes from bacteria from fermented seafood, particularly sea cucumber as novel antithrombotic agents.
Key words: Cardiovascular disease / fermented seafood / fibrinolytic protease / thrombotic agent
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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