| Issue |
BIO Web Conf.
Volume 28, 2020
The 3rd International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BioMIC 2020)
|
|
|---|---|---|
| Article Number | 03003 | |
| Number of page(s) | 4 | |
| Section | Biomolecular and Biotechnology | |
| DOI | https://doi.org/10.1051/bioconf/20202803003 | |
| Published online | 17 December 2020 | |
Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test
1 Clinical Dentistry Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
2 Blood Transfusion Unit, Palang Merah Indonesia, Yogyakarta, Indonesia
3 Department of Periodontology, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
* Corresponding author: kmurdiastuti@ugm.ac.id
Platelet-rich plasma (PRP) rich in growth factors has evolved as an important therapy for periodontal tissue regeneration. A healthy blood donors obtained for homologous PRP (h-PRP). The Freeze-drying h-PRP sample provides an effective method to ensure a longer shelf-life. The h-PRP samples are subjected to crossmatch testing in clinics to prevent any immune response in recipients. The present study aimed to evaluate the differences in donor compatibility on crossmatch test results towards fresh and freeze-dried h-PRP (FD h-PRP). This was a laboratory experiment, h-PRP prepared according to the protocol of blood bank, and 40 recipients blood samples divided into two groups, fresh h-PRP (control group) and FD h-PRP. The crossmatch test was performed to evaluate h-PRP compatibilities by using the gel-test method. The data were analyzed using the chi-square test. The results of the study showed that the crossmatch test on FD h-PRP samples was 100 % compatible and could increase the compatibility results of the donor. the FD h-PRP was safe to become donors and clinical applications.
© The Authors, published by EDP Sciences, 2020
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