| Issue |
BIO Web Conf.
Volume 36, 2021
International Scientific and Practical Conference “Fundamental Scientific Research and Their Applied Aspects in Biotechnology and Agriculture” (FSRAABA 2021)
|
|
|---|---|---|
| Article Number | 06015 | |
| Number of page(s) | 5 | |
| Section | Topical Issues of Veterinary and Animal Science, Biotechnology of Production and Processing of Agricultural Products | |
| DOI | https://doi.org/10.1051/bioconf/20213606015 | |
| Published online | 01 October 2021 | |
Identification of iron by methods of cytochemical analysis in the spleen tissues during experimental radiation pathology
1 Federal Medical and Biological Agency of the Russian Federation, Medical and Sanitary Unit No. 93, Moscow, Russian Federation
2 FSBEI HE “Bashkir State Medical University” Ufa, Russian Federation
3 Bashkir Institute of Technology and Management (branch) Federal State Budget Educational Institution of Higher Education «K.G. Razumovsky Moscow State University of technologies and management (the First Cossack University)», Meleuz, Russia Federation
4 Moscow State Academy of Veterinary Medicine and Biotechnology. K.I. Scriabin, Moscow, Russian Federation
5 Erakond LLC, Sterlitamak, Russian Federation
* Corresponding author: baymatovvaleriy@rambler.ru
The article presents the results of studying the radio protective properties of alfalfa extract (dietary supplement "Erakond"). A decrease in the iron content in macrophages of the red pulp of the spleen was found experimentally using models of experimental radiation pathology induced by ɣ-irradiation of white rats in a single dose of 4 Gy at a dose rate of 1.7 Gy/min. The mechanisms of pathological processes in acute radiation pathology, leading to a decrease in the content of endogenous iron at the systemic, organ, cellular and subcellular levels, have been disclosed. Violation of the processes of enteral absorption of minerals as a result of pronounced destructive-inflammatory processes in the intestinal wall, damage to the hematopoiesis-inducing environment in the red bone marrow, inhibition of cytokine synthesis (IL-1, IL-3, IL-6, IL-7) and granulocytic macrophage colony-stimulating factor (GM-CSF) reduce the level of deposited iron in acute radiation pathology. In rats treated with 40 % "Erakond" aqueous extract before and after irradiation, there is a relatively high level of deposited iron in the spleen tissues in comparison with animals of the comparison group, which were on a general food ration.
© The Authors, published by EDP Sciences, 2021
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