Questions of control of hormone content in fish and other aquatic organisms (metaanalysis)

¹ Federal State Budgetary Institution of Science "Federal Research Center for Nutrition, Biotechnology and Food Safety", 2/14, Ustinsky passage, Moscow, 115446, Russia ;
² First Moscow State Medical University named after I. M. Sechenov, Ministry of Health of the Russian Federation, 2, building 4, str. Bolshaya Pirogovskaya, Moscow, 119435, Russia
³ Federal State Budgetary Scientific Institution "All-Russian Research Institute of Fisheries and Oceanography", 17A, Krasnoselskaya str., Moscow, 107140, Russia

^* Corresponding author: Bagryantseva@ion.ru

Abstract

Between 1995 and 2018, the production of fish and fishery products using feed increased from 12 to 54.3 million tons. In the cultivation of such products in many countries, hormones are widely used as growth stimulants to increase the efficiency of feed conversion for the purpose of sex reversal, as well as for artificial reproduction. Hormones, especially their synthetic forms, are poorly metabolized in the marine organisms, which leads to their accumulation in the food matrix. When they enter the human body, they are capable of accumulation in tissues, affect the endocrine system and can cause the development of a number of metabolic disorders. The possibility of a carcinogenic effect of hormones has been proven. The data presented substantiate the need to control the content of hormones in fish and fish products, develop highly sensitive methods for their detection, establish a list of controlled hormones and hormone-like drugs and safety regulations for food products produced with their use. The most sensitive and accurate method in this case is the HPLC-MS/MS method. We believe that for natural (non-synthetic hormones) and synthetic hormones, the criterion for their absence in the sample should be the sensitivity threshold of the used research method (at least 20 ng/kg).