| Issue |
BIO Web Conf.
Volume 41, 2021
The 4th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BioMIC 2021)
|
|
|---|---|---|
| Article Number | 02005 | |
| Number of page(s) | 1 | |
| Section | Invited Speech | |
| DOI | https://doi.org/10.1051/bioconf/20214102005 | |
| Published online | 22 December 2021 | |
Copy number alterations in cancer: detection and precision medicine
Department of Statistics, University of Leeds, UK
Copy number alterations (CNAs) are genomic alterations where some regions exhibit more or less copy number than the normal two copies. In this talk, I will describe two ideas: (1) how CNAs are estimated from data generated by next generation sequencing (NGS) and what steps are required to make the data interpretable, (2) how the CNA can be utilised for precision medicine in terms of prediction of tumour subtypes and prediction of cancer patients’ survival. If time permits, I will also discuss how to estimate genomic markers from CNA profile across cancer patients.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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