BIO Web Conf.
Volume 41, 2021The 4th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BioMIC 2021)
|Number of page(s)||8|
|Section||Drug Development and Nutraceutical|
|Published online||22 December 2021|
Acceleration of angiogenesis in wound healing after tooth extraction with kirinyuh (Chromolaena odorata) leaf extract
Departement of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Gadjah Mada, 55282, Yogyakarta, Indonesia
2 Undergraduate Student of Faculty of Dentistry, Universitas Gadjah Mada, 55282, Yogyakarta, Indonesia
* Corresponding author: firstname.lastname@example.org
Tooth extraction is dental procedure that causes wound in oral cavity. Kirinyuh leaves (Chromolaena odorata) contain flavonoids, saponins and tannins which help the wound healing after tooth extraction. Purpose of study was to determine effect of giving kirinyuh leaf ethanol extract on wound healing after tooth extraction in guinea pigs (Cavia cobaya) in angiogenesis. Sixty male guinea pigs were divided into five groups: aquadest, iodine glycerine (positive control), kirinyuh 2.5%, 5%, and 10%. Each group consisted of 12 guinea pigs in each group. Kirinyuh leaf extract was prepared in a topical gel with CMC-Na as the solvent. Left mandibular incisor of guinea pigs was extracted then treated according to the group every day. Guinea pigs were euthanized on days 3, 7, 10, and 14 (three guinea pigs from each group per day) and made histological sections with hematoxylin eosin staining. Angiogenesis was observed with binocular microscope equipped with camera. Results showed that number of new blood vessels in kirinyuh 10% group reached highest number faster (day 7) than the other groups (p=0.000). This study concluded that kirinyuh leaves accelerate angiogenesis by increasing the number of blood vessels. The 10% concentration is the most effective kirinyuh extract concentration to accelerate angiogenesis.
© The Authors, published by EDP Sciences, 2021
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