Results of studying of the Brucella suis 245 strain vaccine’s reactogenic properties in an experiment on reindeer

¹ Arctic State Agrotechnological University, 677007, 3, Sergelyakhskoye highway, Yakutsk, Republic of Sakha (Yakutia), Russian Federation
² Yakut Scientific Research Institute of Agriculture, 677001, 23, Bestuzhev-Marlinsky str., Yakutsk, Republic of Sakha (Yakutia), Russian Federation

^* Corresponding author: olgazakharova81@mail.ru

Abstract

Living vaccines are not widely used in practice to prevent and control brucellosis in domesticated reindeer. Brucellosis vaccines from strains 19 or 82 are characterized by a high level of reactogenicity and lead to complications in vaccinated animals. When studying the reactogenic properties of the vaccine from the B. suis 245 strain in the experiment on reindeer, the reaction of the body of domesticated reindeer to the subcutaneous injection of brucella from the B. suis 245 strain was considered. At the same time, no significant differences were observed when the vaccine was administered at a dosage of 10 and 50 billion microbial cells, and the size of edema in millimeters was fixed at the level of 39.0 ± 3.5 and 44.1 ± 2.6, respectively (P> 0.05). The dynamics of the body temperature of animals depending on the method of administration and dose of the vaccine, regardless of the dosage, body temperature, like other indicators of a physiological nature, remained within the normal range. It was found that in the early stages after vaccination, the indicators of the physiological state of the animal’s body are determined by whether the oral or subcutaneous method of administration of the vaccine was used. When vaccinated by the subcutaneous method, reactogenicity was less pronounced with the introduction of 5 billion microbial cells, compared with a dose of 50 billion microbial cells.