The Effect of Nanoliposome Tumeric Extract Gel (Curcuma longa L.) On TNF Alpha Level of Traumatic Ulcer Healing in The Labial Mucosa Wistar Rats (Rattus Norvegicus)

¹ Doctoral program of Medical Faculty, Universitas Airlangga, Surabaya
² Oral Biology Department, Faculty of Dentistry, Universitas Brawijaya, Malang
³ Physiology Department, Faculty of Medical, Airlangga University, Surabaya
⁴ Physiology Department, Faculty of Medical, Universitas Brawijaya, Malang
⁵ Community and Preventive Dentistry Department, Faculty of Dentistry, Universitas Brawijaya, Malang
⁶ Pharmacy Laboratory, Pharmacy Study Program, Faculty of Pharmacy, University of Muhammadiyah, Malang
⁷ Dentistry Study Program, Faculty of Dentistry, Universitas Brawijaya, Malang

^* Corresponding author: bambang_purwanto@fk.unair.ac.id

Abstract

Background: Mucosal ulceration in the oral cavity is very common, especially ulcerations caused by trauma, which are commonly referred to as traumatic ulcers. Based on existing research, turmeric contains active substances in the form of curcumin and flavonoids to accelerate the wound healing process. The wound healing process is a very complex process consisting of 4 phases, namely hemostatic, inflammatory, proliferative, and remodeling phases. Macrophages will also release growth factor TNF alpha which triggers new tissue, after the inflammatory phase. Methods: This study was an experimental study using a randomized post-test only control group design with test animals of Ratus Novergicus. In this study, there were 9 groups, namely the control group, the 0.1% triamcinolone acetonide treatment group, and the turmeric extract nanoliposome gel group, each was given with 3 time series, namely the 3rd, 5th and 7th day. Then IHK preparations were made to see TNF alpha. Results: One way ANOVA test showed differences in TNF Alpha between the control group, the Triamcinolone acetonide, and nanoliposome gel group. TNF alpha shows a deflation amount from day 3, 5 and 7. Nanoliposome group treatment on day 7 had the lowest amount. It can be concluded that the nanoliposome gel of turmeric extract (Curcuma longa L.) has an effect on decreased TNF alpha levels. The decrease of tnf alpha numbers indicates that the inflammatory phase is over and continues to the proliferative and remodeling phase. Conclusion: Based on the results of this study, nanoliposome turmeric extract gel (Curcuma longa L.) has an effect decreased on TNF alpha levels.