| Issue |
BIO Web Conf.
Volume 51, 2022
International Scientific and Practical Conference “From Modernization to Advanced Development: Ensuring Competitiveness and Scientific Leadership of the Agro-Industrial Complex” (IDSISA 2022)
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|---|---|---|
| Article Number | 03005 | |
| Number of page(s) | 7 | |
| Section | Actual Problems of Veterinary Medicine and Microbiology | |
| DOI | https://doi.org/10.1051/bioconf/20225103005 | |
| Published online | 02 August 2022 | |
Peculiarities of the course of acute radiation injury in mice against the background of iodine and selenium preparations
Federal State Budgetary Educational Institution of Higher Education "St. Petersburg State University of Veterinary Medicine", 5, Chernigovskaya Street, St. Petersburg, index 196084, Russia
* Corresponding author: veterenar4ik@mail.ru
In experiments on mice the study of the radioprotective and radiotherapeutic efficacy of the combined use of the selenium-containing feed additive DAFS-25k and the iodine-containing preparation Monclavit-1 was carried out. It has been shown that intragastric administration of DAFS-25k oil solution 3 hours before the total, external, single exposure to γ-radiation, and the subsequent (in 12 hours) intragastric administration of an aqueous solution of Monclavit-1, increases the survival rate of irradiated animals to 67% versus 17% in the control animals. The mechanisms of radioprotective efficacy are assumed to be the antioxidant activity of selenium compounds in DAFS-25k, normalization of thyroid function and relief of gastrointestinal syndrome due to the pronounced antimicrobial activity of Monclavit-1.
© The Authors, published by EDP Sciences, 2022
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