The effect of dexmedetomidine compound nicardipine in transnasal endoscopic pituitary tumor resection

The First Affiliated Hospital of Kunming Medical University, Kunming 650031, China

Abstract

Objective: To compare the effect of dexmedetodeidine and nicardipine alone in transnasal endoscopic pituitary tumor resection, and to find a more suitable controlled antihypertensive regimen. Methods: 40 patients under elective general anesthesia (ASA grade I to I I) were randomly divided into nicardipine group (N group) and dexmedetomidine + nicardipine group (D 0 group), 2 N group). It was the same, before anesthesia initiation (T0), 10min after pumping nicardipine (T1), 20min after (T2), 30min later (T3), 10min after stopping pumping (T4), 20min after (T5), heart rate. Surgical field quality score, bleeding volume, propofol, remifentanil, and nicardipine dosage, respiratory recovery time, extubation time, and adverse effects were recorded. Results: At the 20min time (T4) time, the MAP value of DN group was significantly lower than that of N group, and the difference was statistically significant (P <0.05).At the three moments of 30min (T2), stop pumping (T3) and 20min (T4), the HR value of DN group was lower than group T, and the difference was statistically significant (P <0.05). Both DN and N achieved good surgical field, with no significant differences in anesthesia depth, operation time and bleeding time (P> 0.05); respiratory recovery time in DN was shorter than group N (P <0.05).The incidence of adverse reactions of chills and agitation was higher in the group N than in the DN group, and the difference was statistical significant (P <0.05).Conclusion: separate application of nicardipine in transnasal endoscopic pituitary resection antihypertensive effect is positive, but dexmedetomidine compound nicardipine application in this operation, can reduce propofol, remifentanil anesthetic dosage, heart rate is more stable, also can reduce the incidence of postoperative chills, agitation, than separate application of nicotinate usual effect is better.