| Issue |
BIO Web Conf.
Volume 55, 2022
5th International Conference on Frontiers of Biological Sciences and Engineering (FBSE 2022)
|
|
|---|---|---|
| Article Number | 01022 | |
| Number of page(s) | 5 | |
| DOI | https://doi.org/10.1051/bioconf/20225501022 | |
| Published online | 21 November 2022 | |
Near-infrared Two-region AIE Nanoprobe Study for AD Diagnosis and Treatment Integration
National Institute of Education, Henan University, Kaifeng 475000, China.
* Corresponding author: lyq1903979385@163.com
In this paper, we address the lack of specific targeting of β-amyloid β-protein (Aβ) in the current Alzheimer's disease (AD) diagnosis and treatment, and build a novel AIE nanoprobe molecule based on molecular design and nano-self-assembly technology. Based on the molecular design and nano-self-assembly technology, a new two-component AIE nanoprobe molecule with integrated AD diagnosis and treatment was constructed by co-assembling two-component AIE components. The NIR AIE nanomolecule can effectively penetrate the blood brain barrier (BBB) and depolymerize Aβ fibers, alleviate reactive oxygen species (ROS) in the focal area, and achieve highly sensitive imaging and specific depolymerization.
Key words: AIE probe / Alzheimer's disease / nanocomplex / blood brain barrier / β-amyloid
© The Authors, published by EDP Sciences, 2022
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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