BIO Web Conf.
Volume 57, 2023International Scientific and Practical Conference “Innovations, Technological Solutions and Management in Modern Biotechnology and Biomedicine” (ITSM-2022)
|Number of page(s)||10|
|Section||Biotechnology and Biomedicine|
|Published online||13 January 2023|
Physicochemical, Antibacterial, and Cytotoxic Properties of Composite Materials Based on Biodegradable Poly (Lactic-Co-Glycolic Acid) Functionalized with Zno Nanoparticles
1 Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia
2 Belarusian State University, Minsk, Belarus
* Corresponding author: email@example.com
One of the tasks of modern nanotechnology is the creation of new materials with a wide range of applications and good antibacterial activity. In this work, we developed a new composite material based on poly(lactic-co-glycolic acid) and zinc oxide nanoparticles. The resulting material had a smooth surface without microdefects. The polymer matrix did not affect the generation of reactive oxygen species, 8-oxoguanine, and long-lived protein forms. The addition of ZnO-NPs enhanced the generation of these compounds. The addition of ZnO-NPs to the polymer at a concentration of 0.001-0.1 wt% made it possible to achieve a significant bacteriostatic effect, while not affecting the growth, division, and viability of eukaryotic cells. The resulting composite material is of great interest for biomedical use and the food industry due to controlled biodegradability and antibacterial activity.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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