Effects of BRCA1 and BRCA2 gene mutations on female fertility among Chinese women: A systematic review and meta-analysis

^1. Clinical Medicine, School of Medicine, Yan’an University, Yan’an, Shaanxi, 716000, China
^2. Clinical Medicine, School of Medicine, Yan’an University, Yan’an, Shaanxi, 716000, China
^3. Department of Physical Examination, Xi’an Friendship Hospital, Xi’an, Shaanxi, 710068, China

^* Corresponding author’s e-mail: lamaipeony01@126.com

Abstract

Purpose: It is still inconsistent whether the mutations of BRCAs could reduce the female fertility by increasing the prevalence of breast and ovarian cancer. So we focus on the effects of BRCAs mutations onthe female fertility among Chinese women in this meta-analysis.

Material and Method: The PubMed, Medline, Scopus, Embase, Science Direct, Web of Knowledge and China National Knowledge Infrastructure (CNKI) databases were methodically searched to eclectic relevant studies published from 2000 to 2022 using the key words“BRCA” and “mutation” and “female fertility or ovarian cancer or cervical cancer or breast cancer” and “China or Chinese or Asia or Asian”. The random effects models in RevMan 5.3 software were used to include and evaluate both longitudinal research and randomized controlled trials.

Results: This meta-analysis included 13 studies with a total of 10689 Chinese participants. Contact the control group, positive correlations between the mutations of BRCAs and female cancers were shown among the Chinese women from 35 to 60 years (OR=5.26) (P<0.00001).

Conclusions: The mutations of BRCAs may increase the incidence of cancer among Chinese women, especially the older than 40 years, and reduce female fertility, in which more prospective studies on the fertility outcomes are still needed in the future