| Issue |
BIO Web Conf.
Volume 59, 2023
2023 5th International Conference on Biotechnology and Biomedicine (ICBB 2023)
|
|
|---|---|---|
| Article Number | 02020 | |
| Number of page(s) | 7 | |
| Section | Precision Medicine and Drug Development and Preparation | |
| DOI | https://doi.org/10.1051/bioconf/20235902020 | |
| Published online | 08 May 2023 | |
Preparation of orally disintegrated membranes from liquorice inclusion complexes
Chemical Engineering Institute, Qingdao University of Science and Technology, Qingdao, China
* Corresponding author: wyzhao@qust.edu.cn
Objective: to prepare and evaluate orally disintegrating films of liquorice inclusion complexes. Methods: the active components of Chinese liquorice were extracted by pressurised extraction technique, and the inclusion complexes were prepared by antisolvent method, while the buccal disintegration films of liquorice inclusion complexes were prepared by solvent casting method, and the prepared buccal disintegration films were evaluated. Results: the home-made liquorice inclusion complexes orally disintegrated films formed better films, had good hardness and toughness, the thickness was around 0.1 mm and could disintegrate within 40 s, and the dissolution was rapid, the cumulative release reached 80.1% within 10 min, reaching the immediate release effect. Conclusion: the prepared buccal disintegrating membranes of liquorice inclusion complexes, which are expected to provide new ideas for the development and study of other drugs in the future, deserve further investigation.
© The Authors, published by EDP Sciences, 2023
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