BIO Web Conf.
Volume 60, 20232022 4th International Conference on Biotechnology and Food Science (BFS 2022)
|Number of page(s)||5|
|Section||Biochemical Application and Genetic Engineering|
|Published online||11 May 2023|
The Neurotoxicity Effect and Molecular Mechanism of Fine Particulate Expose-Induced Nervous System Injury
1 Hisense Home Appliance Group Co. LTD, Qingdao, China
2 Hisense Air Conditioning Co., LTD, Qingdao, China
3 Beijing University of Technology, College of Environmental and Energy Engineering, Beijing, China
The potential harm of atmospheric fine particulate matter to human health has been widely concerned around the world. A growing number of studies have shown that PMs exposure can cause damage to respiratory and cardiovascular systems. However, whether PMs can enter the brain and produce neurotoxicity has been an important research topic in the field of neurotoxicity and public health hazards in recent years. In this paper, we review the existing epidemiological evidence and related experimental results to discuss the potential pathways and mechanisms of neurotoxicological effects of PMs on brain. It has been reported that atmospheric PMs can affect the nervous system through the olfactory nerve pathway, blood circulation and other pathways, causing oxidative stress, glial cell activation, neuroinflammation, synaptic plasticity changes and organelle damage and other neurotoxicity. On this basis, it is pointed out that future research in this field should be carried out by multidisciplinary experts in atmospheric chemistry, toxicology and epidemiology.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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