| Issue |
BIO Web Conf.
Volume 60, 2023
2022 4th International Conference on Biotechnology and Food Science (BFS 2022)
|
|
|---|---|---|
| Article Number | 02007 | |
| Number of page(s) | 5 | |
| Section | Agricultural Biotechnology and Food Safety | |
| DOI | https://doi.org/10.1051/bioconf/20236002007 | |
| Published online | 11 May 2023 | |
Pharmacokinetic Modeling of VV116 for Treatment of COVID-19
1 Zibo Experimental Middle School Shandong, China
2 Shanghai Jiao Tong University Shanghai, China
liuzhijunann2020@163.com
virgiathekite@gmail.com
SARS-Cov-2 is still impacting global health and potentially will live with human in the near future. Therefore, effective oral medicines such as VV116 will play an important role in treating numerous patients and ending the pandemic. From this research, these simulated results can be used to guide clinical decisions to maximize therapeutic benefits of VV116 while avoiding potential toxicities. This compartmental modeling approach can be readily used for other drugs that have identical physiochemical properties in the clinical trial. However, caution should be exercised when the dose exceeds the linear PK range (up to 1200 mg in this case), where the model becomes invalid. As such, future study is needed to examine mixed-order or zero order PK where the dose-response is not linear. The importance of biomedical research has also inspired me to pursue a future career to fighting diseases with unmet medical needs.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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