| Issue |
BIO Web Conf.
Volume 61, 2023
6th International Conference on Frontiers of Biological Sciences and Engineering (FBSE 2023)
|
|
|---|---|---|
| Article Number | 01020 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/bioconf/20236101020 | |
| Published online | 21 June 2023 | |
Synthesis of ethyl 4-(2-fluoro-4-nitrophenoxy) picolinate
School of Pharmacy, Jiangxi Science & Technology Normal University, Nan chang 330013, China
* Corresponding author: Zhengpw@126.com
Cancer has seriously affected people's production and life. The appearance of anti-cancer drugs has brought good news to people. Ethyl 4-(2-fluoro-4-nitrophenoxy) picolinate is an important basic skeleton of a small molecule inhibitor of c-Met and a major intermediate in cancer therapy. A rapid and efficient method for the synthesis of compound 8 was established. Compound 8 was synthesized from picolinic acid by acylation and substitution. These steps were weight gain reaction. The synthesis method was optimized and the structure was confirmed by hydrogen NMR spectroscopy.
© The Authors, published by EDP Sciences, 2023
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