| Issue |
BIO Web Conf.
Volume 61, 2023
6th International Conference on Frontiers of Biological Sciences and Engineering (FBSE 2023)
|
|
|---|---|---|
| Article Number | 01024 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/bioconf/20236101024 | |
| Published online | 21 June 2023 | |
The role of mechanical channel in the proliferation and migration of colon cancer
Suzhou Medical College, Soochow University, Jiangsu Province, China
* Corresponding author: 2085830250@qq.com
Piezo channel is the first family of mechanically gated cation channels found in mammals and has been shown correlated with the proliferation and metastasis of tumors in recent years. In a variety of cancer tissues, colon cancer tissues are particularly affected by mechanical stimulation. In this paper, we reported that the role of piezo1 in the proliferation and migration of colon cancer. Firstly, bioinformatics indicated that high levels of piezo1 expression existed in CRC tissues and were associated with poor prognosis. In vitro experiments, SW1116 cells were cultured in DMSO solutions, and CCK-8 assay and transwell assay were separately performed. It turned out that the inhibition of PIEZO1 by Dooku1 resulted in diminished cell proliferation and metastasis, while the activation of PIEZO1 by Yoda1 led to enhanced proliferation and migration of colon cells. Collectively, these findings demonstrated the facilitation role of piezo1 in colon cancer proliferation and migration, suggesting that piezo1 has the potential as a novel therapeutic target for drug design and treatment of colon cancer.
Key words: Piezo1 / Dooku1 / Yoda1 / mechanical channel / colon cancer / proliferation / migration
© The Authors, published by EDP Sciences, 2023
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