Features of the functional activity of melissa officinalis (Melissa officinalis L.) and medicinal mixture based on it

Faculty of Chemistry, Biology and Biotechnology, North Ossetian State University named after K.L. Khetagurov, 362025 Vladikavkaz, Russia

^* Corresponding author: zinahabaeva@mail.ru

Abstract

Using a battery of behavioral models (a black-and-white chamber, an open field and an elevated plus maze), comparative studies of the degree of severity and orientation of the functional activity of melissa officinalis and medicinal mixture based on it were carried out. The work was performed on 30 white female laboratory rats of the Wistar line, weighing 190-220 g. In the case of melissa officinalis monoculture, a wateralcohol tincture of this drug was used and administered orally to the animal on the day of testing. For the preparation of the experimental herbal mixture, the herb of melissa officinalis was used as the basis, as additional components of the mixture - herbs of oregano (Origanum vulgare) and garden sage (Salvia officinalis), hawthorn berries (Crataegus) and common licorice root (Glycyrrhiza glabra) in the ratio 17:10:10:10:10 (per 100 g of experimental herbal mixture: 30 g of melissa officinalis and 17.5 g of the remaining components). The water extraction of the product was carried out in accordance with the existing GOST recommendations. The manifestation of a significant anxiolytic effect of melissa officinalis, manifested by 2 test systems, was revealed. It was found that in the anxiolytic effect of melissa officinalis, the antiphobic component is more pronounced compared to the manifestation of research activity. The experimental medicinal mixture based on melissa officinalis caused, along with an increase in the stress of rats in an unusual situation for them, a more pronounced manifestation of search and research and motor activity.