| Issue |
BIO Web Conf.
Volume 75, 2023
The 5th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BioMIC 2023)
|
|
|---|---|---|
| Article Number | 01002 | |
| Number of page(s) | 14 | |
| Section | Bioinformatics and Data Mining | |
| DOI | https://doi.org/10.1051/bioconf/20237501002 | |
| Published online | 15 November 2023 | |
Citrus Anticancer Research: A Bibliometric Mapping of Emerging Topics
1 Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Indonesia
2 Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
* Corresponding author: fw548@ums.ac.id
Research on the potential anticancer effects of citrus has been widely published in scientific journals. Still, a bibliometric analysis concerning this topic has not been executed. This study employed bibliometric mapping to analyze articles related to citrus anticancer from the Scopus Database and visualized the results using the VOSviewer. In this review, 442 papers published between 1995 and 2023 were selected. Jeju National University in South Korea is recognized as a top contributor. According to the analysis, apoptosis and anticancer are the two specific keywords in the field with the highest co-occurrence. The other keywords in the selected papers were hesperidin, naringenin, nobiletin, apoptosis, and flavonoids. We also found the following steps in this research area: formulation, synthesis, and in vivo preclinical studies. Research trends have shifted from the crude extract to practical applications of specific flavonoid compounds with structure modification to improve their anticancer properties. Still, clinical trials in humans are lacking in this research area and should be further investigated to embrace citrus flavonoids as an anticancer candidate. This analysis and mapping provide a comprehensive understanding of research on the potential anticancer effect of citrus.
Key words: citrus / flavonoid / anticancer / bibliometric / VOSviewer
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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