| Issue |
BIO Web Conf.
Volume 86, 2024
International Conference on Recent Trends in Biomedical Sciences (RTBS-2023)
|
|
|---|---|---|
| Article Number | 01055 | |
| Number of page(s) | 8 | |
| DOI | https://doi.org/10.1051/bioconf/20248601055 | |
| Published online | 12 January 2024 | |
Pancreatic Lipase inhibition assay of various extracts of leaves of Murraya Koenigii in southern areas of Goa
1 Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, Punjab; pearlpinto10@gmail.com
1 # Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, Punjab; louis.23330@lpu.co.in
2 Department of Medical Biochemistry,K S Hegde Medical Academy,Nitte(Deemed to be University), Deralakatte, Mangaluru; drpriya.alva@nitte.edu.in
3 Division of diabetes, Endocrinology and metabolism, Vanderbilt University medical center, Nashville, Tennessee, USA; siva.chinnarasu@vumc.org
4 Department of Internal Medicine, University of Iowa, Iowa, USA, mohanraj-sadasivam@uiowa.edu
* Correspondence: louis.23330@lpu.co.in
The objective of the study was to assess the lipase inhibitory activities of chloroformic, methanolic and aqueous extracts from the commonly available Murraya koenigii (L.) Spreng leaves(Rutaceae) in southern villages of Goa, for potential use in the treatment of obesity. Extracs of the leaves of this plant were evaluated for lipase inhibitory activity using porcine pancreatic lipase (PPL: triacylglycerol lipase) and p-nitrophenyl butyrate in an in vitro assay. Among the three extracts screened, chloroformic extract exhibited the highest pancreatic lipase inhibitory activity of 53.42%, followed by methanolic extract (51.88%) and aqueous extract (36.42%), respectively. Chloroformic extract has not been screened for its pancreatic lipase inhibition assay. All the Crude extracts of leaves of Murraya koenigii (L.) Spreng leaves (Rutaceae) have potential as pancreatic lipase inhibitory agents. . Chloroformic extract was found to be most effective and hence can be used as a potent anti-obesity agent to combat hyperlipidemia.
Key words: Murraya koenigii / pancreatic lipase inhibitory activity / Soxhlet extraction / p-nitrophenyl butyrate / anti-obesity agent
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.