The effect of lypolitics on atherosclerotic plaques of the artery

¹ Center for vascular pathology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
² K. Satbayev Kazakh National Research Technical University, Almaty, 050013, Kazakhstan

^* Corresponding author: darmenov.oralbay@kaznu.kz

Abstract

Endovascular removal of atherosclerotic plaques from the artery is of critical strategic importance, is a new direction and represents a primary task. The innovative capabilities of our invention make it possible to create a sealed cavity in the lumen of the artery with continuous blood flow, and to directly influence atheromas with the drug online. This served as the basis for studying the effect of 8 lipolytics on atheromas of 124 arterial vessels directly on anatomical preparations: 35 coronary, 31 carotid, 51 abdominal aorta and 7 iliac arteries. Visual observation, histology, endoscopy, video endoscopy and scanning electron microscopy during an observation period of 5 minutes to 5 days did not reveal significant changes in the structure, consistency, shape and number of arterial atheromas when exposed to 6 lipolytics, with the exception of Bile acid factors and phosphatidylcholine lipolytics. These lipolytics have demonstrated their effect - reducing the size, loosening and softening the consistency of plaques, as well as facilitating their detachment from the muscle layer and intima of the artery. However, the studied lipolytics did not dissolve or destroy atherosclerotic plaques completely.