| Issue |
BIO Web Conf.
Volume 100, 2024
International Scientific Forum “Modern Trends in Sustainable Development of Biological Sciences” (IFBioScFU 2024)
|
|
|---|---|---|
| Article Number | 02027 | |
| Number of page(s) | 7 | |
| Section | Current Issues in Biotechnology, Microbiology, and Bioengineering | |
| DOI | https://doi.org/10.1051/bioconf/202410002027 | |
| Published online | 08 April 2024 | |
Immunological aspects of chronic kidney disease diagnosed in adult patients
1 Department of Microbiology, Virology and Immunology. Bukhara State Medical Institute
2 Urganch Branch of Tashkent Medical Academy
The purpose of the study was to study the immune status of patients diagnosed with SBK, to develop immunological diagnostic and prognostic criteria. It was found that SD3+- and SD4+-lymphocytes decreased by 1.43 and 1.07 times, SD8+-lymphocytes increased by 1.25 times, and IRI decreased by 1.32 times (T-immunodeficiency). SD25+ lymphocytes increased by 1.80 and 1.59 times, and SD95+ lymphocytes increased by 1.28 and 1.13 times in the blood of these patients. It was found that the amount of SD16+-lymphocytes was reliably increased compared to the parameters of healthy individuals. An imbalance was observed in the concentration of immunoglobulins in blood serum, while IL-4 increased by 11.84 times in patients, IL-6 was reliably reduced by 1.46 times compared to healthy people. Dynamic determination of serum concentrations of IL-4 and IL-6 was recommended as diagnostic and prognostic criteria for patients diagnosed with SBK.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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