| Issue |
BIO Web Conf.
Volume 111, 2024
2024 6th International Conference on Biotechnology and Biomedicine (ICBB 2024)
|
|
|---|---|---|
| Article Number | 02011 | |
| Number of page(s) | 5 | |
| Section | Biomedical Advances and Personalized Medicine | |
| DOI | https://doi.org/10.1051/bioconf/202411102011 | |
| Published online | 31 May 2024 | |
A Study on Hemostatic Properties of Polyphenols Crosslinked Gelatin Microspheres Based on Michael Addition Reaction
Southeast University School of Biological Science and Medical Engineering, State Key Laboratory of Digital Medical Engineering, Nanjing, Jiangsu, China
a First author: 1023494438@qq.com
* Corresponding author: zhangtianzhu@seu.edu.cn
Massive blood loss caused by severe injury is one of the important challenges in the present research of hemostatic materials. In this study, we first prepared polyphenols crosslinked gelatin through Michael addition reaction at 60 °C, and pH = 9.5 for 30 min, herein the mass ratio of polyphenols to gelatin was 1:50. Then emulsion crosslinking method of water-in-oil was used to obtain polyphenols crosslinked gelatin microspheres, including dopamine crosslinked gelatin microspheres (DOPA-GMs) and gallic acid crosslinked gelatin microspheres (GA-GMs). The results showed that the hemostatic microspheres with polyphenols crosslinked gelatin could effectively enhance the hemostatic properties of single-component gelatin microspheres (GMs), and this study provided a new method and strategy for rapid hemostatic microspheres.
© The Authors, published by EDP Sciences, 2024
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