Study on the Targeted Therapy of Colorectal Cancer with Multiple Pathway

School of Pharmaceutical Engineering, Jining Medical University, Jining, 272073, China

^* Corresponding Author's Email: 935103195@qq.com

Abstract

Despite advances in treatment options, colorectal cancer (CRC) still has one of the highest mortalities rates. CRC remains difficult to treat due to the activation of oncogenic signaling pathways such as the Notch pathway, the Wnt signaling pathway and the TGF-β pathway. For the Notch pathway, the activation of Notch pathway inhibits the proliferation of intestinal epithelium and promotes tumor cells invasiveness and metastatic in final. The Wnt pathway controls the expression of downstream protein following the alteration of β-catenin and plays an imperative role in intestinal stem cells (ISCs) self-renewal and cell proliferation without entering differentiation phase. The TGF-β pathway associates with CRC tumor initiation, development and metastasis and played a dichotomous role at different stages of CRC carcinogenesis. In this review, we discuss the mechanisms of action of these three signaling pathways while separately discussing the interaction mechanisms of the corresponding small molecule drug inhibitors with them.