Determination of the relationship between the polymorphic genes of metaloproteinases MMP9 (A-8202G) RS11697325 and the level of cystatin c in children with chronic nephritic syndrome

Samarkand State Medical University, Samarkand, Uzbekistan

^* Corresponding author: parviz.feruza83@mail.ru

Abstract

An analysis of the scientific literature in recent years reliably indicates the importance of molecular diagnostics in the field of nephrology. Research contains information on the role of genetic factors in the chronicization of the process of nephritic syndrome, ongoing research in this area. The pathology of development is explained by the fact that the chronicity of the process occurs primarily due to genetic inferiority of parts of the nephron, which leads to changes in the structure of the protein. The results of the study show the relationship between changes in the genotype of MMP9 (Matrix metalloproteinase-9) (A-8202G) rs11697325 with the development of the chronicization process. Our results provide evidence that cystatin C is an accurate diagnostic and prognostic marker of chronic nephritic syndrome in the pediatric population. At the same time, chromosomal polymorphic MMP9 genes affect the glomerular filtration rate by increasing the amount of Cystatin C, which is a gold marker in the diagnosis of chronic nephritic syndrome in children, determining the prognosis of the disease, which makes it possible for timely treatment and further tactics of the doctor.