Emerging Strategies for Pulp Regeneration: A Comprehensive Review and Clinical Perspectives

Stomatology, Shandong First Medical University, Jinan, Shandong, 250117, China

^* Corresponding author’s email: zsy20000308@126.com

Abstract

Irreversible process pulpitis has brought great pain to patients, and traditional treatment methods have some limitations. Pulp regeneration therapy aims to restore the function of damaged tooth hard tissue and pulp, and can be divided into young permanent tooth apical tissue regeneration and mature permanent tooth pulp regeneration. Root tip induction and revascularization can be used to induce the closure of apical foramen in young permanent teeth. The former has a wide range of applications, but there are problems such as long treatment cycles and low success rates. Revascularization is an emerging method in recent years that has achieved good clinical results. For mature permanent teeth, the ability of autogenous regeneration is limited, and Stem-cell therapy, utilizing tissue engineering techniques, can promote pulp regeneration, but it is still in the experimental research stage. Different types of scaffolds and growth factors play an important role in pulp regeneration. At present, there is a lack of unified induction and comprehensive clinical and experimental evaluation of methods for pulp regeneration. Therefore, this article reviews the strategies for pulp regeneration and evaluates the advantages and disadvantages of each method, in order to improve the success rate and effectiveness of clinical application.