The role of Leptin (hormone adipocytes) and its effect on Osteoporosis in postmenopausal women

Department of Biology, Faculty of Science, University of Kufa, Najaf, Iraq

^* Corresponding author: haiderkamw3@gmail.com

Abstract

Leptin has been recognized as a critical factor in regulating energy expenditure and bone cell function. The role of Leptin in regulating osteocyte function within the adipocyte population has been widely recognized. Leptin stimulates bone cell proliferation and plays a role in developing many skeletal disorders, regulatory mechanisms and mode of action of Leptin. This suggests that levels of Leptin are linked to obesity (BMI). The primary aim of this study was to examine the potential relationship between circulating leptin levels and BMI, as well as specific indices such as t-score and biomarkers in postmenopausal women. Blood samples were collected from (90) postmenopausal women, (35) who were diagnosed with Osteoporosis, (25) samples who were diagnosed with Osteopenia, and (30) samples as a control group. Patients were diagnosed as osteoporotic and controls as usual by measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DEXA). The results of bone turnover markers, which included Leptin hormone in the sera of Osteoporotic patients, was 211.30± 65.24 (pg/mL) less than it was in the sera of control women mean of 283.20 ±106.15 (pg/mL), indicating a significant increase for the comparison is 0.002. The study showed that low levels of Leptin lead to low bone density, which leads to Osteoporosis.